Identification of Gene Biomarkers for Tigilanol Tiglate Content in Fontainea picrosperma

Tigilanol tiglate (EBC-46) is a small-molecule natural product under development for the treatment of cancers in humans and companion animals. The drug is currently produced by purification from the Australian rainforest tree Fontainea picrosperma (Euphorbiaceae). As part of a selective-breeding pro...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2022-06, Vol.27 (13), p.3980
Hauptverfasser:	Mitu, Shahida A, Stewart, Praphaporn, Tran, Trong D, Reddell, Paul W, Cummins, Scott F, Ogbourne, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-cancer Biomarkers Biosynthesis biosynthesis pathway Breeding CYP94C1 Cytochrome Cytochrome P450 Cytochromes P450 Dehydration Diterpenes - chemistry Enzymes Esters - chemistry Euphorbiaceae - chemistry Euphorbiaceae - genetics Fontainea picrosperma Gene expression Gene Expression Regulation, Plant Genes Genes, Plant Genetic Markers Leaves Metabolites Natural products Plant Breeding Plant Leaves - chemistry Plant Leaves - genetics Plant Roots - chemistry Plant Roots - genetics Predation Proteins R protein Rainforests Reductases Roots Selective breeding tigilanol tiglate
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Zusammenfassung:	Tigilanol tiglate (EBC-46) is a small-molecule natural product under development for the treatment of cancers in humans and companion animals. The drug is currently produced by purification from the Australian rainforest tree Fontainea picrosperma (Euphorbiaceae). As part of a selective-breeding program to increase EBC-46 yield from F. picrosperma plantations, we investigated potential gene biomarkers associated with biosynthesis of EBC-46. Initially, we identified individual plants that were either high (>0.039%) or low EBC-46 (
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27133980