Prognostic Value and Outcome for ETV6/RUNX1-Positive Pediatric Acute Lymphoblastic Leukemia: A Report From the South China Children's Leukemia Group

To analyzed the outcome of ETV6/RUNX1-positive pediatric acute B lymphoblastic leukemia (B-ALL) with the aim of identifying prognostic value. A total of 2,530 pediatric patients who were diagnosed with B-ALL were classified into two groups based on the ETV6/RUNX1 status by using a retrospective coho...

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Veröffentlicht in:	Frontiers in oncology 2021-12, Vol.11, p.797194-797194
Hauptverfasser:	Qiu, Kun-Yin, Xu, Hong-Gui, Luo, Xue-Qun, Mai, Hui-Rong, Liao, Ning, Yang, Li-Hua, Zheng, Min-Cui, Wan, Wu-Qing, Wu, Xue-Dong, Liu, Ri-Yang, Chen, Qi-Wen, Chen, Hui-Qin, Sun, Xiao-Fei, Jiang, Hua, Long, Xing-Jiang, Chen, Guo-Hua, Li, Xin-Yu, Li, Chang-Gang, Huang, Li-Bin, Ling, Ya-Yun, Lin, Dan-Na, Wen, Chuan, Kuang, Wen-Yong, Feng, Xiao-Qin, Ye, Zhong-Lv, Wu, Bei-Yan, He, Xiang-Lin, Li, Qiao-Ru, Wang, Li-Na, Kong, Xian-Ling, Xu, Lu-Hong, Li, Chi-Kong, Fang, Jian-Pei
Format:	Artikel
Sprache:	eng
Schlagworte:	acute B lymphoblastic leukemia ETV6/RUNX1 multicenter cohort study Oncology outcome prognosis
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Zusammenfassung:	To analyzed the outcome of ETV6/RUNX1-positive pediatric acute B lymphoblastic leukemia (B-ALL) with the aim of identifying prognostic value. A total of 2,530 pediatric patients who were diagnosed with B-ALL were classified into two groups based on the ETV6/RUNX1 status by using a retrospective cohort study method from February 28, 2008, to June 30, 2020, at 22 participating ALL centers. In total, 461 (18.2%) cases were ETV6/RUNX1-positive. The proportion of patients with risk factors (age
ISSN:	2234-943X 2234-943X
DOI:	10.3389/fonc.2021.797194