T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV

T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV

Neuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effectiv...

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Veröffentlicht in:Brain, behavior, & immunity. Health behavior, & immunity. Health, 2022-11, Vol.25, p.100498-100498, Article 100498
Hauptverfasser: Williams, Dionna W., Flores, Bianca R., Xu, Yanxun, Wang, Yuezhe, Yu, Danyang, Peters, Brandilyn A., Adedimeji, Adebola, Wilson, Tracey E., Merenstein, Daniel, Tien, Phyllis C., Cohen, Mardge H., Weber, Kathleen M., Adimora, Adaora A., Ofotokun, Igho, Fischl, Margaret, Turan, Janet, Turan, Bülent, Laumet, Geoffroy, Landay, Alan L., Dastgheyb, Raha M., Gange, Stephen J., Weiser, Sheri D., Rubin, Leah H.
Format: Artikel
Sprache:eng
Schlagworte:
Cognition
Full Length
HIV
Mental health
T-cell function
Women
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Zusammenfassung:Neuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effective immune response (activation, co-stimulation/normal function, exhaustion, senescence) and neuropsychiatric complications in WWH. 369 WWH (78% HIV RNA undetectable/
ISSN:2666-3546
2666-3546
DOI:10.1016/j.bbih.2022.100498