Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity

Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets...

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Veröffentlicht in:Journal of Obesity 2011-01, Vol.2011 (2011), p.362-375
Hauptverfasser: Sears, Barry, Ricordi, Camillo
Format: Artikel
Sprache:eng
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Zusammenfassung:Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities.
ISSN:2090-0708
2090-0716
DOI:10.1155/2011/431985