Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

ABBREVIATIONSCDR: complementarity determining region; FACS: fluorescence-activated cell sorting; ka: association rate; kd: dissociation rate; KD: dissociation constant; scFv: single-chain variable fragment; SPR: surface plasmon resonance.

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Veröffentlicht in:mAbs 2022-12, Vol.14 (1), p.2115200-2115200
Hauptverfasser: Teixeira, Andre A. R., D’Angelo, Sara, Erasmus, M. Frank, Leal-Lopes, Camila, Ferrara, Fortunato, Spector, Laura P., Naranjo, Leslie, Molina, Esteban, Max, Tamara, DeAguero, Ashley, Perea, Katherine, Stewart, Shaun, Buonpane, Rebecca A., Nastri, Horacio G., Bradbury, Andrew R. M.
Format: Artikel
Sprache:eng
Schlagworte:
Affinity maturation
CDR shuffling
developability
liability
library construction
off-rate
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Zusammenfassung:ABBREVIATIONSCDR: complementarity determining region; FACS: fluorescence-activated cell sorting; ka: association rate; kd: dissociation rate; KD: dissociation constant; scFv: single-chain variable fragment; SPR: surface plasmon resonance.
ISSN:1942-0862
1942-0870
DOI:10.1080/19420862.2022.2115200