Dietary risk of neonicotinoid insecticides through fruit and vegetable consumption in school-age children

Although the systemic property of neonicotinoid (neonics) has become the most widely used insecticide worldwide since late 1990s, the current literature offers limited information about the human dietary intake and the potential risks of neonics. In this study, we aimed to assess the cumulative risk of total neonics intakes through fruit and vegetable consumption in 58 children ages 8–12 participated in the Hangzhou China (HZC) study over 5 consecutive weekends. Individual neonic residues in each food item were aggregated using the relative potency factor approach into a single metric (IMIRPF), representing dietary intakes of imidacloprid-equivalent total neonics. We then estimated the average daily intake (ADI) of total neonics through fruit and vegetable consumption and evaluated the cumulative dietary risk of neonics. All of the 123 samples were detected with at least one neonic. Commonly consumed foods, such as carrots, green vegetables, baby cabbage, and apple were found with more than 6 neonics. The estimated ADIs of total neonics vegetable and fruit consumption using the mean IMIRPF for apples and green vegetables, two most consumed food items, were 237.1*10−6 and 106.8*10−6 mg/kg/day, respectively. Although the estimated ADIs were below the current chronic reference dose (cRfD) of imidacloprid, we have stipulated the possible future downward revision of cRfD. The potential health risk of neonics to children via dietary exposure should raise more public concern considering the increase use of neonics and the ubiquitous presence in fruits and vegetables. •We aimed to assess the dietary risk of total neonicotinoids through fruit and vegetable consumption in school-aged children.•We used the relative potency factor approach to integrate all neonicotinoid residues in each food sample into a single metric.•The cumulative dietary risk of neonicotinoids through fruit and vegetable consumption was evaluated using the average daily intakes.•The estimated average daily intakes were not exceeded the chronic reference dose for imidacloprid, regardless the ubiquity of neonicotinoids in fruits and vegetables.•We have stipulated the possible future downward revision of the chronic reference dose for neonicotinoids for protecting public health.