Elevated plasma sRAGE and IGFBP7 in heart failure decrease after heart transplantation in association with haemodynamics

Aims Metabolic derangement is implicated in the pathophysiology of heart failure (HF) and pulmonary hypertension (PH). We aimed to identify the dynamics of metabolic plasma proteins linked to end‐stage HF and associated PH in relation to haemodynamics, before and after heart transplantation (HT). Me...

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Veröffentlicht in:	ESC Heart Failure 2020-10, Vol.7 (5), p.2340-2353
Hauptverfasser:	Ahmed, Abdulla, Ahmed, Salaheldin, Arvidsson, Mattias, Bouzina, Habib, Lundgren, Jakob, Rådegran, Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Cardiac and Cardiovascular Systems Cardiac arrhythmia Cardiac catheterization Cardiomyopathy Cardiovascular disease Case-Control Studies Clinical Medicine Diabetes Ejection fraction Extracellular matrix Growth factors Haemodynamics Heart failure Heart Failure - surgery Heart Transplantation Heart transplants Hemodynamics Humans Hypertension Immunoassay Insulin resistance Insulin-Like Growth Factor Binding Proteins - blood Insulin-like growth factors Intubation Kardiologi Klinisk medicin Lipoproteins Low density lipoprotein receptors Medical and Health Sciences Medicin och hälsovetenskap Metabolism Original Original s Patients Peptides Plasma Population Proteins Proteomics Pulmonary hypertension Receptor for Advanced Glycation End Products Stroke Transplants & implants
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Zusammenfassung:	Aims Metabolic derangement is implicated in the pathophysiology of heart failure (HF) and pulmonary hypertension (PH). We aimed to identify the dynamics of metabolic plasma proteins linked to end‐stage HF and associated PH in relation to haemodynamics, before and after heart transplantation (HT). Methods and results Twenty‐one metabolic plasma proteins were analysed with proximity extension assay in 20 controls and 26 patients before and 1 year after HT. Right heart catheterizations were performed in the HF patients pre‐operatively and 1 year after HT. Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and insulin‐like growth factor‐binding protein 7 (IGFBP7) were higher in HF patients compared with controls (P
ISSN:	2055-5822 2055-5822
DOI:	10.1002/ehf2.12772