Medial forebrain bundle stimulation after failed subcallosal cingulate deep brain stimulation for treatment-resistant depression: Efficacy of a dual deep brain stimulation system for depression

•The use of MFB DBS for depression can be efficacious even in those patients who fail DBS at a separate target.•Having both MFB and SCC DBS seems to augment the treatment response in terms of patient-reported HAM-D score.•The increased efficacy of both systems together is likely due to combinatorial targeting of underlying disease networks.