Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results

Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that u...

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Veröffentlicht in:	Emerging infectious diseases 2020-10, Vol.26 (10), p.2501-2503
Hauptverfasser:	Das, Marie K, Chaudhary, Anu, Bryan, Andrew, Wener, Mark H, Fink, Susan L, Morishima, Chihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Viral - blood Automation Betacoronavirus - immunology Clinical Laboratory Techniques - methods Comparative analysis coronavirus coronavirus disease Coronavirus Infections - blood Coronavirus Infections - diagnosis Coronaviruses COVID-19 COVID-19 Testing COVID19 Diagnosis Health aspects Hospital patients Humans Immunoassay Immunoglobulin G Immunoglobulin G - blood Immunology Laboratories Mass Screening - methods Pandemics Patients Pneumonia, Viral - blood Pneumonia, Viral - diagnosis Proteins Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results Reproducibility of Results Research Letter SARS-CoV-2 Serologic Tests Severe acute respiratory syndrome coronavirus 2 viruses
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Beschreibung
Zusammenfassung:	Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that uses z-scores to enable rapid and efficient comparison of serologic test performance.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2610.202632