Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment

Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment

Although several therapeutics are used to treat coronavirus disease 2019 (COVID-19) patients, there is still no definitive metabolic marker to evaluate disease severity and recovery or a quantitative test to end quarantine. Because severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects...

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Veröffentlicht in:Molecular therapy. Methods & clinical development 2022-09, Vol.26, p.266-278
Hauptverfasser: Daniell, Henry, Nair, Smruti K., Shi, Yao, Wang, Ping, Montone, Kathleen T., Shaw, Pamela A., Choi, Grace H., Ghani, Danyal, Weaver, JoEllen, Rader, Daniel J., Margulies, Kenneth B., Collman, Ronald G., Laudanski, Krzysztof, Bar, Katharine J.
Format: Artikel
Sprache:eng
Schlagworte:
angiotensin-converting-enzyme
biomarker
coronavirus disease
COVID-19
Original
plasma marker
saliva marker
SARS-CoV-2 diagnosis/treatment, soluble Angiotensin-Converting Enzyme 2, biomarker in plasma/saliva, Corona virus, COVID-19 disease, ACE2 activity/concentration, RAS pathway
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Zusammenfassung:Although several therapeutics are used to treat coronavirus disease 2019 (COVID-19) patients, there is still no definitive metabolic marker to evaluate disease severity and recovery or a quantitative test to end quarantine. Because severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects human cells via the angiotensin-converting-enzyme 2 (ACE2) receptor and COVID-19 is associated with renin-angiotensin system dysregulation, we evaluated soluble ACE2 (sACE2) activity in the plasma/saliva of 80 hospitalized COVID-19 patients and 27 non-COVID-19 volunteers, and levels of ACE2/Ang (1–7) in plasma or membrane (mACE2) in lung autopsy samples. sACE2 activity was markedly reduced (p 
ISSN:2329-0501
2329-0501
DOI:10.1016/j.omtm.2022.07.003