New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity
Five new chromone derivatives, arthones A⁻E ( ⁻ ), together with eight known biogenetically related cometabolites ( ⁻ ), were isolated from a deep-sea-derived fungus sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of and wer...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2018-08, Vol.23 (8), p.1982 |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Five new chromone derivatives, arthones A⁻E (
⁻
), together with eight known biogenetically related cometabolites (
⁻
), were isolated from a deep-sea-derived fungus
sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of
and
were established by electronic circular dichroism (ECD) calculations and that of
was determined by modified Mosher ester method. Compounds
and
exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC
values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM. |
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| ISSN: | 1420-3049 1420-3049 |
| DOI: | 10.3390/molecules23081982 |