Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Two new copper( ) complexes [CuL ] ( ) and [CuL ] ( ) derived from azo-based ligands 2-hydroxy-5- -tolylazo-benzaldehyde (HL ) and 1-(2-hydroxy-5- -tolylazo-phenyl)-ethan-one (HL ) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magneti...

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Veröffentlicht in:Open Chemistry 2022-06, Vol.20 (1), p.505-516
Hauptverfasser: Tripathi, Mamta, Asatkar, Ashish Kumar, Antony, Stalin, Dash, Mrinal Kanti, Roymahapatra, Gourisankar, Pande, Rama, Sarkar, Avijit, Aldakheel, Fahad M., Binshaya, Abdulkarim S., Alharthi, Nahed S., Alaofi, Ahmed L., Alqahtani, Mohammed S., Syed, Rabbani
Format: Artikel
Sprache:eng
Schlagworte:
azo
complexes
copper
copper(ii) complexes
ct-DNA
DFT
molecular docking
t-RNA
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Zusammenfassung:Two new copper( ) complexes [CuL ] ( ) and [CuL ] ( ) derived from azo-based ligands 2-hydroxy-5- -tolylazo-benzaldehyde (HL ) and 1-(2-hydroxy-5- -tolylazo-phenyl)-ethan-one (HL ) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance ( H and C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2022-0164