Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism

Voltage-gated potassium (Kv) channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels share similar structures but have opposite gating polarity. Kv channels have a strong coupling (>10 ) between the voltage sensor (S4) and the activation gate: when S4s are activated, the g...

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Veröffentlicht in:	International journal of molecular sciences 2024-04, Vol.25 (8), p.4309
Hauptverfasser:	Wu, Xiaoan, Cunningham, Kevin P, Bruening-Wright, Andrew, Pandey, Shilpi, Larsson, H Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Charged particles electromechanical coupling Equilibrium HCN channels Humans Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Ion Channel Gating Kv channels Medical equipment and supplies industry Medical test kit industry Mutation Patch-Clamp Techniques Physiological aspects Probability Sensors voltage clamp fluorometry voltage gating
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Beschreibung
Zusammenfassung:	Voltage-gated potassium (Kv) channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels share similar structures but have opposite gating polarity. Kv channels have a strong coupling (>10 ) between the voltage sensor (S4) and the activation gate: when S4s are activated, the gate is open to >80% but, when S4s are deactivated, the gate is open
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms25084309