Angiotensin II Type-1 Receptor Antibody in Solid Organ Transplantation - Is It Time to Test?

Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving Banff AMR diagnostic classification system and...

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Veröffentlicht in:	Transplant international 2024-11, Vol.37, p.13280
Hauptverfasser:	Martin, Paul James Patrick, Willicombe, Michelle, Roufosse, Candice
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody mediated rejection AT1R AT1R antibody Graft Rejection - immunology Health Archive Histocompatibility Testing - methods Humans Kidney Transplantation - adverse effects non-HLA antibody Organ Transplantation Receptor, Angiotensin, Type 1 - immunology rejection
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Beschreibung
Zusammenfassung:	Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving Banff AMR diagnostic classification system and refinement of recommendations for histocompatibility testing by the Sensitization in Transplantation Assessment of Risk (STAR) workgroup. This mini-review discusses the latest understanding of pathophysiological mechanisms, clinical evidence for the pathogenicity of AT1R-Ab, and methods of laboratory testing.
ISSN:	1432-2277 0934-0874 1432-2277
DOI:	10.3389/ti.2024.13280