Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study

•Fat mass and obesity-associated gene (FTO) is a significant epigenetic modifier.•We included 5180 subjects (70 died from COVID-19 and 341 from other causes).•GG homozygotes had a higher risk of death from COVID-19 (odds ratio = 2.01; P

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of infectious diseases 2024-11, Vol.148, p.107232-None, Article 107232
Hauptverfasser:	Hubacek, Jaroslav A., Capkova, Nadezda, Bobak, Martin, Pikhart, Hynek
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Cohort Studies COVID-19 COVID-19 - genetics COVID-19 - mortality COVID-19 - virology Female FTO Genetic Predisposition to Disease Humans Male Middle Aged Mortality Polymorphism Polymorphism, Single Nucleotide SARS-CoV-2 SARS-CoV-2 - physiology
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Beschreibung
Zusammenfassung:	•Fat mass and obesity-associated gene (FTO) is a significant epigenetic modifier.•We included 5180 subjects (70 died from COVID-19 and 341 from other causes).•GG homozygotes had a higher risk of death from COVID-19 (odds ratio = 2.01; P
ISSN:	1201-9712 1878-3511 1878-3511
DOI:	10.1016/j.ijid.2024.107232