In vitro study of mefenamatestarch as drug delivery system

تم أسترة حامض المفينامك مع النشا بنسبة مولية [1 : 1] كتعويض دواء على بوليمر طبيعي لغرض إطالة فترة التحرر الدوائي و لفوائد أخرى. شخص البوليمر الدوائي الجديد بواسطة طيف الأشعة تحت الحمراء و الأشعة فوق البنفسجية و طيف الرنين النووي المغناطيسي. قيست الصفات الفيزيائية و درست سرع التحرر الدوائي المحكم بدوال حامضية 1.1 و 7.4 للمعدة و الأمعاء و بدرجة 37°م. Mefenamic acid was esterified with starchwith [1 : 1] Molar ratio, as drug substituted with natural polymer, to prolongthe period of hydrolysis of drug polymer with other advantages. The new prodrug starch was characterized by FT-IR and UV-Visible and 1H-NMR spectroscopies. The physical properties were studied and controlled drug release was studied in different pH values at 37oC. The stability of drug was carried out by measuring the absorbance of mefenamic starch which hydrolyzed in HCl solution of pH 1.1 (artificial gastric fluid) and phosphate buffer of pH 7.4 (simulating intestinal fluid SIF) at 37oC for several days. The thermal analysis such as DSC was studied.