Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease

Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and...

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Veröffentlicht in:	Scientific reports 2017-07, Vol.7 (1), p.6306-10, Article 6306
Hauptverfasser:	Lin, Chin-Hsien, Chaudhuri, K. Ray, Fan, Jun-Yu, Ko, Chia-I., Rizos, Alexandra, Chang, Chia-Wen, Lin, Han-I., Wu, Yih-Ru
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 692/617/375/1718 Age of Onset Aged Alleles Catechol O-methyltransferase Catechol O-Methyltransferase - genetics Chronic pain Chronic Pain - genetics Depression - complications Female Genetic Association Studies Genetic diversity Genetic Predisposition to Disease Genotype & phenotype Genotypes Humanities and Social Sciences Humans Male Mental depression Methyltransferase Middle Aged Movement disorders multidisciplinary NAV1.7 Voltage-Gated Sodium Channel - genetics Neurodegenerative diseases Pain Pain Measurement Parkinson Disease - complications Parkinson's disease Polymorphism, Single Nucleotide Receptors, Opioid, mu - genetics Science Science (multidisciplinary) Severity of Illness Index
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Zusammenfassung:	Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and rs4680 of COMT , rs6746030 of SCN9A , and rs1799971 of OPRM1 . In total, 193 participants (46.2%) experienced pain. Compared to pain-free PD patients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depression and motor severity ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-017-06782-z