Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

Two new succinimide-containing derivatives, cladosporitins A ( ) and B ( ), were isolated from the fermentation cultures of the mangrove-derived fungus sp. HNWSW-1, along with a new pyrone, clapone ( ), as well as the previously reported talaroconvolutin A ( ) and anthraquinone ( ). The structures o...

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Veröffentlicht in:	Marine drugs 2018-12, Vol.17 (1), p.4
Hauptverfasser:	Wang, Pei, Cui, Yan, Cai, Caihong, Chen, Huiqin, Dai, Yu, Chen, Pengwei, Kong, Fandong, Yuan, Jingzhe, Song, Xinming, Mei, Wenli, Dai, Haofu
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - metabolism Anthraquinone Anthraquinones Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological Products - isolation & purification Biological Products - pharmacology Cell Line, Tumor Cell lines Cladosporium Cladosporium - chemistry Cladosporium sp Cytotoxicity Enzyme Assays Fermentation Fungi Glycosidases Glycoside Hydrolase Inhibitors - isolation & purification Glycoside Hydrolase Inhibitors - pharmacology Humans Hydrocarbons Inhibitory Concentration 50 mangrove-derived fungus Mangroves Metabolites Molecular Structure NMR Nuclear magnetic resonance Phenols Plant Roots - microbiology Proton Magnetic Resonance Spectroscopy Rhizophoraceae - microbiology Spectral analysis Spectrum analysis Succinimide succinimide-containing derivatives Succinimides - isolation & purification Succinimides - pharmacology Toxicity Two dimensional analysis α-glycosidase inhibitor
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Zusammenfassung:	Two new succinimide-containing derivatives, cladosporitins A ( ) and B ( ), were isolated from the fermentation cultures of the mangrove-derived fungus sp. HNWSW-1, along with a new pyrone, clapone ( ), as well as the previously reported talaroconvolutin A ( ) and anthraquinone ( ). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC values of 29.4 ± 0.35 μM, 25.6 ± 0.47 μM, and 41.7 ± 0.71 μM, respectively, whereas compound exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC values of 14.9 ± 0.21 μM and 26.7 ± 1.1 μM, respectively. In addition, compounds and displayed inhibitory activity against α-glycosidase, with IC values of 78.2 ± 2.1 μM and 49.3 ± 10.6 μM, respectively.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md17010004