The relationship between the mode of presentation, CT‐derived body composition, systemic inflammatory grade and survival in colon cancer
Background Within colorectal cancer, the systemic inflammatory response (SIR) and CT‐derived body composition, particularly the loss of lean muscle mass, are independently associated with oncological outcomes; however, no study has included both non‐metastatic and metastatic disease. The present stu...
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Veröffentlicht in: | Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2022-12, Vol.13 (6), p.2863-2874 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background
Within colorectal cancer, the systemic inflammatory response (SIR) and CT‐derived body composition, particularly the loss of lean muscle mass, are independently associated with oncological outcomes; however, no study has included both non‐metastatic and metastatic disease. The present study analyses the association between body composition, mode of presentation, SIR and survival in patients with TNM I–IV colon cancer.
Methods
Patients diagnosed with colon cancer from 2011 to 2014 were identified. The SIR was stratified using systemic inflammatory grade (SIG). Staging CT scans were used to define body composition: subcutaneous fat index (SFI), visceral fat area (VFA), skeletal muscle index (SMI) and skeletal muscle density (SMD). The effect of SIG and body composition on mode of presentation and 3‐year overall survival (3‐yr OS) was analysed.
Results
One thousand one hundred forty‐six patients were identified; 14%/38%/40%/8% had TNM Stage I/II/III/IV colon cancer, respectively. Patients were predominantly aged 65 + (63%), male (52%) and BMI > 25 (62%). 79%74% had a high SFI/VFA, and 56%/62% had a low SMI/SMD, respectively. Abnormal body composition was prevalent across all disease stages and associated with TNM stage—high SFI in 87%/76%/81%/68% (P |
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ISSN: | 2190-5991 2190-6009 |
DOI: | 10.1002/jcsm.13097 |