Effect of Neoadjuvant Treatment on TRG, Surgical Complications and LARS in Patients with Rectal Cancer

Objective To investigate the effects of different neoadjuvant treatments on tumor regression, surgical complications and low anterior resection syndrome (LARS) in patients with rectal cancer. Methods We included 127 patients with rectal cancer receiving neoadjuvant treatments, and they were divided into long-term concurrent chemoradiotherapy group (n=42), short-term radiotherapy+chemotherapy group (n=39) and chemotherapy group (n=46). The pathological results, clinical data and follow-up results were collected. The factors that may affect tumor regression, surgical complications and low anterior resection syndrome after rectal cancer surgery were statistically analyzed and concluded. Results The pCR rates were 28.51%, 10.3% and 8.6% in long-term concurrent chemoradiotherapy group, short-term radiotherapy+chem otherapy group and chemotherapy group, respectively. There were 14 (33.33%), 9 (23.07%) and 10 (21.74%) patients with perioperative complications in three groups, respectively. A total of 91 patients wer