Repair, protection and regeneration of spinal cord injury

Reading guide 1954 Nanodrug-coated three-dimensional microelectronic stent used in axon regeneration after spinal cord injury 1955 Macrophage polarization and spinal cord injury repair 1957 Inhibiting the RhoA signaling pathway promotes regeneration of axons and myelin sheath 1958 Microsurgical lysis of spinal cord nerve roots for the treatment of spinal cord injury 1959 Local manipulation of the growth cone cytoskeleton: new strategies to promote axon regeneration 1961 Interaction of miR-21 and TGF-β/SMADs signaling pathway affects the formation of fibrotic scars after spinal cord injury 1962 Elucidating the molecular mechanisms of CSPG-mediated axon growth inhibition through phosphoproteomics analysis 1963 The repair of spinal cord injury with multifunctional, three-dimensional, electroactive scaffolds 1964 A strategy for treating spinal cord injury: targeting the variation of immune cells in the local microenvironment 1965 Epidemiological data is critical for decreasing the incidence of spinal cord injury 1966 The importance of olfactory ensheathing cells for spinal cord injury 1967 Optogenetics: a new method to repair urination dysfunction after spinal cord injury? 1968 Effects of zinc on the recovery of neurological function after spinal cord injury 1969 Durotomy and dural grafting to treat lower cervical spine injuries with extensive spinal cord edema 1971 Reconstruction of artificial micturition reflex arc for neurogenic bladder after spinal nerve injury 1972 Old drugs, new tricks: the strategy for new drug development in spinal cord injury Nanodrug-coated three-dimensional microelectronic stent used in axon regeneration after spinal cord injury Nerve repair after spinal cord injury (SCI) requires orderly growth, migration, and transmission of neuronal signals in the regenerated nerve fibers at the injury site. Using light and electron microscopy, we studied the morphological characteristics in the junction between the nerve stump and new material [Figure 4], neuronal survival at the proximal and distal ends of the defect, and survival of the motor end plate of the distal skeletal muscle. Microglia expresses numerous macrophage-associated molecular markers, such as cluster of differentiation (CD) molecule 11b, CD14, and F4/80. [...]in the CNS, microglia are generally considered to be the resident macrophage where they can maintain CNS homeostasis and are thus regarded as the most important innate immune cell (Casano et al., 2015; Hu et al., 2015).