Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

L. (PV) has been used to treat autoimmune thyroiditis (AIT), but the underlying mechanism remains unknown. The present study was designed to evaluate the effect of PV on AIT and explore the role of high-mobility group box-1 (HMGB1) signaling in PV-mediated effects in vivo and in vitro. In the presen...

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Veröffentlicht in:	Drug design, development and therapy development and therapy, 2021-01, Vol.15, p.4559-4574
Hauptverfasser:	Guo, Qingling, Qu, Haili, Zhang, Hong, Zhong, Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antibodies Attenuation Autoimmune diseases autoimmune thyroiditis (ait) Bioactive compounds Biological activity Cell culture Chromosomal proteins Cytokines Cytokines - metabolism Disease Models, Animal Experimental autoimmune thyroiditis Female Gene expression Helper cells hmgb1 HMGB1 protein HMGB1 Protein - metabolism Hypothyroidism Immunomodulation In vitro methods and tests In vivo methods and tests Inflammation Interleukin 6 Lipopolysaccharides Lymphocytes T Mitogens Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes mRNA MyD88 protein Original Research Pathogenesis Photovoltaic cells Plant Extracts - pharmacology Proteins Prunella - chemistry Prunella vulgaris prunella vulgaris l Pyruvic acid Rats Rats, Inbred Lew Rosmarinic acid Signal transduction Signal Transduction - drug effects Signaling Solvents Spleen Splenocytes Th1 Cells - immunology Th17 Cells - immunology Th2 Cells - immunology Thyroid Thyroid gland Thyroiditis Thyroiditis, Autoimmune Thyroiditis, Autoimmune - drug therapy Thyroiditis, Autoimmune - immunology tlr9 Toll-Like Receptor 9 - metabolism Tumor necrosis factor-TNF
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Zusammenfassung:	L. (PV) has been used to treat autoimmune thyroiditis (AIT), but the underlying mechanism remains unknown. The present study was designed to evaluate the effect of PV on AIT and explore the role of high-mobility group box-1 (HMGB1) signaling in PV-mediated effects in vivo and in vitro. In the present study, bioactive components of PV were identified using UPLC-ESI-MS. The protective effects and potential mechanisms critical for the anti-inflammatory and immunomodulatory effects of PV in AIT were investigated in a rat model of thyroglobulin-induced experimental autoimmune thyroiditis (EAT) and in lipopolysaccharide (LPS)-induced thyroid follicular cells (TFCs). The main bioactive compound identified in PV was rosmarinic acid. The thyroid volume, thyroiditis inflammation score and serum thyroglobulin antibody levels of EAT rats were attenuated by PV treatment (
ISSN:	1177-8881 1177-8881
DOI:	10.2147/DDDT.S325814