The Significance of Immunoglobulins in Cystic Fibrosis: Normal or High?

Aim: Cystic fibrosis (CF) is characterized by local and chronic inflammation accompanied by increased neutrophil and macrophage counts, high elastase levels, and inflammatory cytokines due to impaired haemostasis. Changes in immunoglobulin (Ig) levels may occur due to recurrent chronic infections and may be associated with the deterioration of respiratory functions. In this study, we aimed to evaluate the interaction of high Ig levels with respiratory functions and chronic infections in CF. Materials and Methods: The diagnosis of the patients CF was made in accordance with the "National CF Diagnosis and Treatment Guidelines". The socio-demographic characteristics, Ig values, and the pulmonary function tests were evaluated according to age group. Results: A total of 107 patients were included in this study. The patients' median age was 65 (6-200) months. It was found that those patients with high IgG (p=0.01) and IgA (p