Identification of anti-diabetes peptides from Spirulina platensis

Inhibitory effects of the identified peptides (RR, LR and GK) and drug Sitaglipin. [Display omitted] •Spirulina platensis protein had anti-diabetes activities in IR cell model.•Anti-diabetes peptides were identified from S. platensis for the first time.•11 anti-diabetes peptides were identified from S. platensis protein.•LRSELAAWSR displayed the best activities on and DPP-IV. In this study, ultrasound coupled with subcritical water (USW) technology was employed to extract S. platensis protein, and its inhibitory effect on three enzymes (α-amylase, α-glucosidase and dipeptidyl peptidase-4 (DPP-IV)) was evaluated. Subsequently, using insulin resistant-HepG2 cell model, the data presented that the USW-extracted protein significantly (p