Sustained AMP-activated protein kinase activation attenuates the activity of brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in mice exposed to chronic stress

In the present study, we used 7,8-dihydroxyflavone to activate its receptor TrkB and evaluated its effects on neurogenesis and synaptogenesis. [...]we applied a pharmacological intervention approach by the pretreatment of TrkB antagonist, AMPK inhibitor/activator to assess the changes in behaviors, neurogenesis, and synaptogenesis in depressive-like mice. [...]AMPK activity was dependent on BDNF/TrkB activation in depressive-like animals. AMPK inactivation reversed the impairments in hippocampal synaptic plasticity in mice induced by amyloid β. [...]it is rational to hypothesize that the activity of AMPK is conditional in response to stress and antidepressants. Yi LT, Wang SS, Cheng J, Chen M, Zhu JX, Li CF, Dong SQ, Liu Q. Sustained AMP-activated protein kinase activation attenuates the activity of brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in mice exposed to chronic stress.