Global Dynamics of a Stochastic Viral Infection Model with Latently Infected Cells

In this paper, we study the global dynamics of a stochastic viral infection model with humoral immunity and Holling type II response functions. The existence and uniqueness of non-negative global solutions are derived. Stationary ergodic distribution of positive solutions is investigated. The soluti...

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Veröffentlicht in:Applied sciences 2021-11, Vol.11 (21), p.10484
Hauptverfasser: Rajivganthi, Chinnathambi, Rihan, Fathalla A.
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Sprache:eng
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Zusammenfassung:In this paper, we study the global dynamics of a stochastic viral infection model with humoral immunity and Holling type II response functions. The existence and uniqueness of non-negative global solutions are derived. Stationary ergodic distribution of positive solutions is investigated. The solution fluctuates around the equilibrium of the deterministic case, resulting in the disease persisting stochastically. The extinction conditions are also determined. To verify the accuracy of the results, numerical simulations were carried out using the Euler–Maruyama scheme. White noise’s intensity plays a key role in treating viral infectious diseases. The small intensity of white noises can maintain the existence of a stationary distribution, while the large intensity of white noises is beneficial to the extinction of the virus.
ISSN:2076-3417
2076-3417
DOI:10.3390/app112110484