Features of carbohydrate metabolism in women of early reproductive age with polycystic ovary syndrome

Background. Fertility of women, especially with an endocrine hyperandrogenic imbalance, requires special attention, as incidence of reproductive losses in this group reaches almost 67 %. The objective is to determine the correlation between body mass index, violations of carbohydrate metabolism and vitamin D level in clinical symptoms of polycystic ovary syndrome (PCOS). Materials and me­thods. Hormonal analysis is conducted during days 5–7 of menstrual cycle by evaluating serum levels of follicle-stimu­lating and luteinizing hormones, testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, dehydrotestosterone in 45 women with PCOS aged 18–25 years. Results. The relationship between vitamin D content and hormonal maintenance of the reproductive system in women with PCOS has been traced; a trigger role of redu­cing the level of vitamin D has been shown in the formation of hormonal imbalance and clinical hyperandrogenic manifestations of insulin resistance in women with PCOS. Conclusions. Patients with PCOS and insufficient level of vitamin D, despite the absence of excessive body weight and obesity, have more significant changes in carbohydrate metabolism than patients without PCOS.