Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis

Four novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Marine drugs 2012-02, Vol.10 (2), p.319-328
Hauptverfasser:	Li, Yongxin, Xu, Ying, Liu, Lingli, Han, Zhuang, Lai, Pok Yui, Guo, Xiangrong, Zhang, Xixiang, Lin, Wenhan, Qian, Pei-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antibacterial Aquatic Organisms - isolation & purification Aquatic Organisms - metabolism Bacillus subtilis Bacillus subtilis - isolation & purification Bacillus subtilis - metabolism Coumarins - adverse effects Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology cytotoxicity Drug Discovery Fermentation Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects HeLa Cells Humans Indian Ocean Inhibitory Concentration 50 lipoamicoumacin Marine Microbial Sensitivity Tests Molecular Structure Proteobacteria - drug effects Structure-Activity Relationship Thioctic Acid - analogs & derivatives Thioctic Acid - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Four novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md10020319