Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners

Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners

Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling. We sought to evaluate the role of sIL 6R as a regulator of IL-6-induced vascular remodeling. Forty-four m...

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Veröffentlicht in:Frontiers in physiology 2021-10, Vol.12, p.722528-722528
Hauptverfasser: Villar-Fincheira, Paulina, Paredes, Aaron J., Hernández-Díaz, Tomás, Norambuena-Soto, Ignacio, Cancino-Arenas, Nicole, Sanhueza-Olivares, Fernanda, Contreras-Briceño, Felipe, Mandiola, Jorge, Bruneau, Nicole, García, Lorena, Ocaranza, María Paz, Troncoso, Rodrigo, Gabrielli, Luigi, Chiong, Mario
Format: Artikel
Sprache:eng
Schlagworte:
exercise
interleukin-6
Physiology
runners
soluble interleukin-6 receptor
vascular smooth muscle cell
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Zusammenfassung:Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling. We sought to evaluate the role of sIL 6R as a regulator of IL-6-induced vascular remodeling. Forty-four male marathon runners were recruited and allocated into two groups: low-training (LT,
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2021.722528