Determination of modifiable risk factors for length-for-age z-scores among resource-poor Indonesian infants

To reduce the burden of early-life linear growth faltering in low- and middle-income countries, interventions have focused on nutrition strategies, sometimes combined with water quality, sanitation, and hygiene (WASH). However, even when combined, their effects on linear growth have been inconsisten...

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Veröffentlicht in:PloS one 2021-02, Vol.16 (2), p.e0247247-e0247247
Hauptverfasser: Diana, Aly, Haszard, Jillian J, Sari, Sri Y Irda, Rahmannia, Sofa, Fathonah, Annisha, Sofiah, Wina Nur, Rizqi, Haidar, Haekal, Raulia, Gilmartin, Allissia, Harper, Michelle, Petri, William, Houghton, Lisa, Gibson, Rosalind
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Sprache:eng
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Zusammenfassung:To reduce the burden of early-life linear growth faltering in low- and middle-income countries, interventions have focused on nutrition strategies, sometimes combined with water quality, sanitation, and hygiene (WASH). However, even when combined, their effects on linear growth have been inconsistent. Here, we investigate potential predictors of length-for-age z-scores (LAZ) in a cohort of resource-poor rural Indonesian infants to inform the optimal strategies to reduce linear growth faltering. Apparently healthy rural breastfed Indonesian infants were randomly selected from birth registries at age 6 months (n = 230) and followed up at 9 (n = 202) and 12 (n = 190) months. Using maximum likelihood estimation, we examined longitudinal relationships among socio-demographic status, maternal height, infant sex, age, water source, sanitation facility, energy, protein, micronutrient intakes and biomarkers (serum ferritin, zinc, retinol binding protein (RBP), selenium-adjusted for inflammation), and α-1-acid glycoprotein (AGP) and C-reactive protein (CRP) (systemic inflammation biomarkers) at age 6 and 9 months on LAZ at age 9 and 12 months. Stunting (LAZ
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0247247