Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B

Highlights • We experienced a patient with possible cerebral mucormycosis due to Lichtheimia. • We applied qPCR assay to cerebrospinal fluid (CSF) as well as serum. • We detected a higher Mucorales DNA load in CSF than in serum. • Intravenous administration of liposomal amphotericin B can decrease M...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of infectious diseases 2014-12, Vol.29 (C), p.200-202
Hauptverfasser:	Shigemura, Tomonari, Nakazawa, Yozo, Matsuda, Kazuyuki, Motobayashi, Mitsuo, Saito, Shoji, Koike, Kenichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amphotericin B - administration & dosage Amphotericin B - therapeutic use Antifungal Agents - administration & dosage Antifungal Agents - therapeutic use Brain Diseases - diagnosis Brain Diseases - drug therapy Brain Diseases - microbiology Cerebrospinal fluid DNA, Fungal - cerebrospinal fluid Humans Infectious Disease Lichtheimia Liposomal amphotericin B Male Mucorales - genetics Mucormycosis Mucormycosis - diagnosis Mucormycosis - drug therapy Mucormycosis - microbiology Pulmonary/Respiratory Quantitative PCR Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We experienced a patient with possible cerebral mucormycosis due to Lichtheimia. • We applied qPCR assay to cerebrospinal fluid (CSF) as well as serum. • We detected a higher Mucorales DNA load in CSF than in serum. • Intravenous administration of liposomal amphotericin B can decrease Mucorales in CSF.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2014.10.019