P76 Established risk alleles at HLA-A, -DPB1, -DQB1 and -DRB1 for systemic lupus erythematosus associate with distinct clinical manifestations

ObjectiveWe aimed to investigate associations between disease manifestations of SLE and HLA risk alleles relevant to Danish subjects of European ancestry.MethodsHLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 alleles were assigned from whole genome sequence data of 25,215 Scandinavian samples, called by Graphtyper, and imputed into 270,627 chiptyped Danes as described,1 including 427 SLE patients of Danish descent, previously characterized with respect to demographic, clinical and genotypic characteristics2 and controls available by collaboration with the Danish Blood Donor Study. Logistic regression was used for association testing of the imputed alleles with SLE. For SLE patients, associations between HLA risk alleles and SLE disease manifestations according to the ACR-1997 classification criteria were examined by multivariate logistic regression analyses adjusted for age and sex; one model for each disease manifestation. ResultsWe identified eight HLA alleles that associate significantly (p