The genetic landscape of basal ganglia and implications for common brain disorders

The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europe...

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Veröffentlicht in:	Nature communications 2024-10, Vol.15 (1), p.8476-14, Article 8476
Hauptverfasser:	Bahrami, Shahram, Nordengen, Kaja, Rokicki, Jaroslav, Shadrin, Alexey A., Rahman, Zillur, Smeland, Olav B., Jaholkowski, Piotr P., Parker, Nadine, Parekh, Pravesh, O’Connell, Kevin S., Elvsåshagen, Torbjørn, Toft, Mathias, Djurovic, Srdjan, Dale, Anders M., Westlye, Lars T., Kaufmann, Tobias, Andreassen, Ole A.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/43 45/43 631/208/205/2138 631/378/2583 692/308/2056 Adult Aged Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Apolipoprotein E Basal ganglia Basal Ganglia - diagnostic imaging Brain Brain architecture Brain Diseases - genetics Brain Diseases - pathology Cognition Disorders Female Ganglia Gene loci Genetic analysis Genetic Predisposition to Disease Genome-Wide Association Study Humanities and Social Sciences Humans Liability Male Mendelian Randomization Analysis Mental disorders Middle Aged Molecular structure Motor task performance multidisciplinary Multivariate analysis Neostriatum Neurodegenerative diseases Neurodevelopment Neurodevelopmental disorders Neurogenesis Neurological diseases Nucleus accumbens Parkinson Disease - genetics Parkinson's disease Polymorphism, Single Nucleotide Replication Science Science (multidisciplinary) White People - genetics
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Zusammenfassung:	The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans. Our multivariate GWAS identified 72 genetic loci associated with basal ganglia volumes with a replication rate of 55.6% at P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-024-52583-0