Altered nitric oxide induced by gut microbiota reveals the connection between central precocious puberty and obesity

[...]the adipose tissue in obese children would secret leptin, which stimulates the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH), also participating the earlier onset of puberty. Since gut microbiota (GM) associated with the hormone secretion and obesity,3 it inspires us to detect the mechanism of GM in triggering CPP, and explore their roles for the co-occurrence of obesity and CPP. Notably, we also discovered that NO synthesis positively correlated to FSH and insulin (Figure 3E). Since NO also promote insulin resistance which leads to obesity, these positive correlations confirmed the impact of NO on both CPP and OW. [...]we should apply metagenomic sequencing to detect GM functions. [...]our study identified a number of CPP-associated bacteria, emphasized the importance of bacterial-synthesized neurotransmitters on CPP, and illustrated the shared GM features in CPP and OW patients, suggesting potentials of microbial therapies in future CPP treatment.