Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: A French nationwide multicenter cohort study—ANRS0001s COV-POPART

This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in people living with HIV (PWH) and HIV-negative individuals. We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two...

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Veröffentlicht in:	International journal of infectious diseases 2024-09, Vol.146, p.107110, Article 107110
Hauptverfasser:	Loubet, Paul, Lelievre, Jean-Daniel, François, Alexis, Botelho-Nevers, Elisabeth, Chidiac, Christian, Chirio, David, Dubee, Vincent, Dussol, Bertrand, Galtier, Florence, Hessamfar, Mojgan, Hodaj, Enkelejda, Jaffuel, Sylvain, Lacombe, Karine, Laine, Fabrice, Lefebvre, Maeva, Maakaroun-Vermesse, Zoha, Makinson, Alain, Portefaix, Aurelie, Pourcher, Valerie, Rey, David, Zucman, David, Longobardi, Julie, Bertheau, Mathilde, Tartour, Eric, de Lamballerie, Xavier, Launay, Odile, Wittkop, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood CD4 Lymphocyte Count Cohort Studies COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Female France HIV HIV Infections - immunology Humans Immunity, Humoral Immunization, Secondary Immunogenicity Immunoglobulin G - blood Life Sciences Male Middle Aged Santé publique et épidémiologie SARS-CoV-2 SARS-CoV-2 - immunology Vaccination Vaccines Viral Load
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Zusammenfassung:	This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in people living with HIV (PWH) and HIV-negative individuals. We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (
ISSN:	1201-9712 1878-3511 1878-3511
DOI:	10.1016/j.ijid.2024.107110