1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for studies was characterized and monitored by H NMR. Antiproliferative activity studies...

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Veröffentlicht in:Toxicology reports 2015-01, Vol.2 (C), p.377-383
Hauptverfasser: Domracheva, Ilona, Muhamadejev, Ruslan, Petrova, Marina, Liepinsh, Edvards, Gulbe, Anita, Shestakova, Irina, Duburs, Gunars, Arsenyan, Pavel
Format: Artikel
Sprache:eng
Schlagworte:
1H NMR
5-Fluorouracil
Carmofur
Cytotoxicity
DMPC
Drug delivery
Short Communication
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Zusammenfassung:Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for studies was characterized and monitored by H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media.
ISSN:2214-7500
2214-7500
DOI:10.1016/j.toxrep.2015.01.009