A Straightforward Synthesis of Functionalized cis -Perhydroisoquinolin-1-ones

A Straightforward Synthesis of Functionalized cis -Perhydroisoquinolin-1-ones

Base-catalyzed annulation reactions of 5,6-dihydro-2(1 )-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized -perhyd...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2019-02, Vol.24 (3), p.557
Hauptverfasser: Arioli, Federica, Pérez, Maria, Are, Celeste, Molins, Elies, Bosch, Joan, Amat, Mercedes
Format: Artikel
Sprache:eng
Schlagworte:
5,6-dihydro-2(1H)-pyridone
Carbon
Chemical reactions
Chromatography
Michael addition
Natural products
Nazarov reagents
Nitrogen
perhydroisoquinoline
Polarity
Reagents
Solvents
stereoselectivity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Base-catalyzed annulation reactions of 5,6-dihydro-2(1 )-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized -perhydroisoquinolin-1-ones.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24030557