From in vitro survey to establish the scienticfic foundation for the detection of nasopharyngeal carcinoma by combined infection factor and aberrant genetics

Nasopharyngeal carcinoma is the common cancer in Vietnam counting for 3,3% in 2012. Therefore, there are necessary to prognosis and early diagnosis nasopharyngeal carcinoma in order to improve the survival of patients. Current studies affirmed that the infection of EBV (Epstein-Barr virus) and the aberrant methylation in DAPK gene were the reasons leading to the carcinogenesis of nasopharynx. For the aims to establish the method based on the present of EBNA-1 which was necessary to the infection and replication of EBV and the hypermethylation in DAPK as the biomarker for prognosis and early diagnosis nasopharyngeal carcinoma, in this study, we carried out (1) Data mining and statistically calculated the mean of methylation frequencies of DAPK based on the studies worldwide; (2) Determination of the mode of experiment for prognosis and early diagnosis the nasopharyngeal carcinoma.