The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes

T cell receptor (TCR) signaling influences multiple aspects of CD4 and CD8 T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines a...

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Veröffentlicht in:Frontiers in immunology 2021-02, Vol.11, p.615371-615371
Hauptverfasser: Clark, Matthew, Kroger, Charles J, Ke, Qi, Tisch, Roland M
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Sprache:eng
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Zusammenfassung:T cell receptor (TCR) signaling influences multiple aspects of CD4 and CD8 T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines also affect TCR signaling duration, as well as accessory pathways that further shape a T cell response. Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing β cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms. In this review, we will discuss how the strength and nature of TCR signaling events influence the development of self-reactive T cells and drive the progression of T1D through effects on T cell gene expression, lineage commitment, and maintenance of pathogenic anti-self T cell effector function.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.615371