Molecular Epidemiology of Group A Streptococcus Infections in The Gambia

Molecular Epidemiology of Group A Streptococcus Infections in The Gambia

Molecular epidemiological data on Group A (GAS) infection in Africa is scarce. We characterized the types and -clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the potential for strain mistyping, we used a newly published primer for -typing. The...

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Veröffentlicht in:Vaccines (Basel) 2021-02, Vol.9 (2), p.124
Hauptverfasser: Jabang, Sona, Erhart, Annette, Darboe, Saffiatou, Baldeh, Aru-Kumba, Delforge, Valerie, Watson, Gabriella, Foster-Nyarko, Ebenezer, Salaudeen, Rasheed, Lawal, Bolarinde, Mackenzie, Grant, Botteaux, Anne, Antonio, Martin, Smeesters, Pierre R, On Behalf Of The Mrcg StrepA Study Group
Format: Artikel
Sprache:eng
Schlagworte:
African studies
Antigens
Communication
emm-cluster
emm-type
Epidemiology
group A streptococcus
Infections
Medical laboratories
Meningitis
Pneumonia
Proteins
Skin
Streptococcus
Streptococcus infections
Surveillance
The Gambia
vaccine
Vaccine development
Vaccines
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Zusammenfassung:Molecular epidemiological data on Group A (GAS) infection in Africa is scarce. We characterized the types and -clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the potential for strain mistyping, we used a newly published primer for -typing. There was considerable strain diversity, highlighting the need for vaccine development offering broad strain protection.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9020124