The Emerging Roles of CCN3 Protein in Immune-Related Diseases

The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major c...

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Veröffentlicht in:	Mediators of inflammation 2021, Vol.2021, p.5576059-8
Hauptverfasser:	Peng, Linan, Wei, Yingying, Shao, Yijia, Li, Yi, Liu, Na, Duan, Lihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Cell adhesion & migration Cell Differentiation Cell migration Cell Movement Cell Proliferation Cyclin-dependent kinases Cytokines Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - metabolism Endothelial Cells - metabolism Extracellular matrix Extracellular Matrix - metabolism Fibroblasts Fibrosis Glomerulonephritis - immunology Glomerulonephritis - metabolism Growth factors Heparan sulfate Humans Immune System - physiopathology Kinases Medical prognosis Melanoma Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Neoplasms - immunology Neoplasms - metabolism Nephroblastoma Overexpressed Protein - physiology Osteoarthritis Osteoarthritis - immunology Osteoarthritis - metabolism Prostate cancer Proteins Review Scleroderma Scleroderma (Disease) Scleroderma, Systemic - immunology Scleroderma, Systemic - metabolism Structure-function relationships Systemic scleroderma Systemic sclerosis Tumors
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Zusammenfassung:	The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major cellular processes such as cell growth, migration, and differentiation. Recently, CCN3 has emerged as a critical regulator in a variety of diseases, including immune-related diseases, including rheumatology arthritis, osteoarthritis, and systemic sclerosis. In this review, we will briefly introduce the structure and function of the CCN3 protein and summarize the roles of CCN3 in immune-related diseases, which is essential to understand the functions of the CCN3 in immune-related diseases.
ISSN:	0962-9351 1466-1861
DOI:	10.1155/2021/5576059