Niveles de anticuerpos bactericidas frente a meningococo C tras la vacunación de niños de 2 a 6 años de edad en Andalucía

Background: In 1997, 18.58 of the cases of Meningoxococcacal l Disease caused b serogroup C in Andalusia were cluldren between 2 and 4 years of age; ages where the initial inunune response and the duration of tlte capsular A+C meninpococcal polyssacharide vaccine is less than in older age groups. Research was designed in aorde- to nilelxa-- ure the immuue response produced by this vaccine in children from 2 to 6 yeurs of age and to compare it with the natural irnmuni:y present in unvaccinated children. Methods: 1. Dual monitoring study: a) groups of ctlildren vaccinated previously and control groups, b) groups of children who were going to be vaccinated, for pre and post-vaccination (1. G and 12 months) analysis and a control group. II. The bactericida1 acllvity was measured according to the standxdised protocol of the CDC with regard to the strain of N. rnerkyiridi.\ C-l 1 The sera wlth bactericida1 activity (TAB) z 1.8 were consldered to be protective. Results: 1 and 2 months followinrg vaccination,. tlle poropuortion of TAB > 1:8 was significantly higher t&haann that of the conbtoro¡ l group (65.69 and 73% in comparison to 2 2% and 12%). In the pre-vaccme and post-vaccine (after 6, 7, 12 and 13 months) verification. no significant difference between vaccinated indlviduals and con-rols was observed. Conclusious: The differences between vaccinated and unvaccinated mdividuals 1 and 2 months following vaccination indicate seroconversion in the vaccinated individuals. For the age group of between 2 to 6 years of age, the bactericida1 actlvity acquired decline quickly, as, after 6 months, differences between this group ant1 the control group are nno o longer observed. Meningccócica por serogrupo C en Andalucía fueron niños de 2 a 4 años de edad; edades donde respuesta inmune inicial y duración de la vacuna antimeningocócica de polisactido capsular A+C, es menor que en edades superiores. Se diseñó una investigación para medir la respuesta inmune producida por esta vacuna, en niños de 2 a 6 años de edad, y compararla con la inmunidad natural presente en milos no vacunados. Métodos: 1. Doble estudio de seguimiento: J) grupos de niños previamente vacunados y grupos control, b) grupo de niños que iba a ser vacunado, para análisis pre y postvacunal(l.6 y 12 meses) y grupo control. II.- La actividad bactericida se midió según protocolo estandarizado del CDC frente a cepa de N. rnehyírih C-11. Los sueros con título de actividad bactericida (TAB)> 1.8 se consideraron