Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound p...

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Veröffentlicht in:ACS omega 2019-11, Vol.4 (20), p.18663-18667
Hauptverfasser: Magnin, Geraldine, Bissel, Philippe, Council-Troche, Roberto McAlister, Zhou, Zhiguo, Ehrich, Marion
Format: Artikel
Sprache:eng
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Zusammenfassung:In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M–1 indicates that this binding was not covalent.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.9b02587