Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits their antibacterial properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is su...

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Veröffentlicht in:Bioactive materials 2021-12, Vol.6 (12), p.4389-4401
Hauptverfasser: Wang, Xianwen, Shi, Qianqian, Zha, Zhengbao, Zhu, Dongdong, Zheng, Lirong, Shi, Luoxiang, Wei, Xianwen, Lian, Lian, Wu, Konglin, Cheng, Liang
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Sprache:eng
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Zusammenfassung:Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits their antibacterial properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. Cu SASs/NPC have stronger peroxidase-like catalytic activity, glutathione (GSH)-depleting function, and photothermal property compared with non-Cu-doped NPC, indicating that Cu doping significantly improves the catalytic performance of nanozymes. Cu SASs/NPC can effectively induce peroxidase-like activity in the presence of H2O2, thereby generating a large amount of hydroxyl radicals (•OH), which have a certain killing effect on bacteria and make bacteria more susceptible to temperature. The introduction of near-infrared (NIR) light can generate hyperthermia to fight bacteria, and enhance the peroxidase-like catalytic activity, thereby generating additional •OH to destroy bacteria. Interestingly, Cu SASs/NPC can act as GSH peroxidase (GSH-Px)-like nanozymes, which can deplete GSH in bacteria, thereby significantly improving the sterilization effect. PTT-catalytic synergistic antibacterial strategy produces almost 100% antibacterial efficiency against Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA). In vivo experiments show a better PTT-catalytic synergistic therapeutic performance on MRSA-infected mouse wounds. Overall, our work highlights the wide antibacterial and anti-infective bio-applications of Cu single-atom-containing catalysts. [Display omitted] •Uniform Cu SASs/NPC were fabricated by a pyrolysis-etching-adsorption-pyrolysis strategy.•Cu SASs/NPC showed excellent photothermal, catalytic, and GSH-depleted properties.•Cu SASs/NPC obtained satisfactory PTT-catalytic synergistic antibacterial performance.
ISSN:2452-199X
2452-199X
DOI:10.1016/j.bioactmat.2021.04.024