An efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones/imines via a Lewis base catalyzed Biginelli-type reaction under solvent-free conditions

An efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones/imines via a Lewis base catalyzed Biginelli-type reaction under solvent-free conditions

3,4-Dihydropyrimidin-2(1H)-one, 3,4-dihydropyrimidin-2(1H)-thione, and 3,4-dihydropyrimidin-2(1H)-imine derivatives were synthesized by modified Biginelli cyclocondensation reaction catalyzed by triphenylphosphine as Lewis base. The structures of the synthesized compounds have been elucidated by IR,...

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Veröffentlicht in:Arabian journal of chemistry 2016-09, Vol.9 (S1), p.S846-S851
Hauptverfasser: Sheik Mansoor, S., Syed Shafi, S., Zaheer Ahmed, S.
Format: Artikel
Sprache:eng
Schlagworte:
3,4-Dihydropyrimidine
Biginelli reaction
Cyclocondensation
Triphenylphosphine
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Zusammenfassung:3,4-Dihydropyrimidin-2(1H)-one, 3,4-dihydropyrimidin-2(1H)-thione, and 3,4-dihydropyrimidin-2(1H)-imine derivatives were synthesized by modified Biginelli cyclocondensation reaction catalyzed by triphenylphosphine as Lewis base. The structures of the synthesized compounds have been elucidated by IR, 1H NMR and elemental analysis.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2011.09.018