Extrapulmonary small cell sarcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

Background Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. Case presentation We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by...

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Veröffentlicht in:World journal of surgical oncology 2008-09, Vol.6 (1), p.102-102, Article 102
Hauptverfasser: Hueser, Christopher N, Nguyen, Nghi C, Osman, Medhat, Havlioglu, Necat, Patel, Anjali J
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Sprache:eng
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Zusammenfassung:Background Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. Case presentation We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed small cell carcinoma. Serial PET/CT scans of the entire body failed to reveal any extracranial [ super(18)F]2-fluoro-2-deoxy-D-glucose (FDG) avid lesions at either diagnosis or follow-up. Conclusion Chemotherapy may show a transient response in the treatment of EPSCC. Further studies are needed to help identify optimal treatment strategies. Combination PET/CT technology may be a useful tool to monitor EPSCC and assess for an occult primary malignancy.
ISSN:1477-7819
1477-7819
DOI:10.1186/1477-7819-6-102