LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

The role of long noncoding RNA (LncRNA) ADAMTS9 antisense RNA 2 (ADAMTS9-AS2) is unclear in lung adenocarcinoma (LUAD). The aim of this study was to explore the relationship between ADAMTS9-AS2 and LUAD, based on The Cancer Genome Atlas (TCGA) database and bioinformatics analysis. Various statistica...

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Veröffentlicht in:International journal of general medicine 2021-01, Vol.14, p.8541-8555
Hauptverfasser: Lin, Zhichao, Huang, Wenhai, Yi, Yongsheng, Li, Dongbing, Xie, Zehua, Li, Zumei, Ye, Min
Format: Artikel
Sprache:eng
Schlagworte:
adamts9-as2 antisense rna 2
Adenocarcinoma
Analysis
Antisense RNA
biomarker
Biomarkers
Cancer
Cancer therapies
Cell cycle
Gender
Gene expression
Genetic aspects
Genomes
Genomics
immune infiltration
Logistics
lung adenocarcinoma
Lung cancer
Medical prognosis
Original Research
Prognosis
Regression analysis
Tumors
Variables
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Zusammenfassung:The role of long noncoding RNA (LncRNA) ADAMTS9 antisense RNA 2 (ADAMTS9-AS2) is unclear in lung adenocarcinoma (LUAD). The aim of this study was to explore the relationship between ADAMTS9-AS2 and LUAD, based on The Cancer Genome Atlas (TCGA) database and bioinformatics analysis. Various statistical methods, Kaplan-Meier method, Cox regression analysis, GSEA, and immune infiltration analysis were used to evaluate the relationship between clinical features and ADAMTS9-AS2 expression, prognostic factors, and the significant involvement of ADAMTS9-AS2 in function. In LUAD patients, low expression of ADAMTS9-AS2 was associated with N stage (P=0.011), gender (P=0.002), number of packs smoked (P=0.024) and smoker (P
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S340683