Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19

Most data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have been presented as case series without comparison to patients with other acute respiratory illnesses. We examined emergency department patients between February 3 and March 31, 2020 with an acute respirat...

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Veröffentlicht in:EClinicalMedicine 2020-10, Vol.27, p.100518-100518, Article 100518
Hauptverfasser: Shah, Sachin J., Barish, Peter N., Prasad, Priya A., Kistler, Amy, Neff, Norma, Kamm, Jack, Li, Lucy M., Chiu, Charles Y., Babik, Jennifer M., Fang, Margaret C., Abe-Jones, Yumiko, Alipanah, Narges, Alvarez, Francisco N., Botvinnik, Olga Borisovna, Castaneda, Gloria, Dadasovich, Rand M., Davis, Jennifer, Deng, Xianding, DeRisi, Joseph L., Detweiler, Angela M., Federman, Scot, Haliburton, John, Hao, Samantha, Kerkhoff, Andrew D., Kumar, G. Renuka, Malcolm, Katherine B., Mann, Sabrina A., Martinez, Sandra, Mary, Rupa K., Mick, Eran, Mwakibete, Lusajo, Najafi, Nader, Peluso, Michael J., Phelps, Maira, Pisco, Angela Oliveira, Ratnasiri, Kalani, Rubio, Luis A., Sellas, Anna, Sherwood, Kyla D., Sheu, Jonathan, Spottiswoode, Natasha, Tan, Michelle, Yu, Guixia, Kangelaris, Kirsten Neudoerffer, Langelier, Charles
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Sprache:eng
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Zusammenfassung:Most data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have been presented as case series without comparison to patients with other acute respiratory illnesses. We examined emergency department patients between February 3 and March 31, 2020 with an acute respiratory illness who were tested for SARS-CoV-2. We determined COVID-19 status by PCR and metagenomic next generation sequencing (mNGS). We compared clinical presentation, diagnostics, treatment, and outcomes. Among 316 patients, 33 tested positive for SARS-CoV-2; 31 without COVID-19 tested positive for another respiratory virus. Among patients with additional viral testing (27/33), no SARS-CoV-2 co-infections were identified. Compared to those who tested negative, patients with COVID-19 reported longer symptoms duration (median 7d vs. 3d, p 
ISSN:2589-5370
2589-5370
DOI:10.1016/j.eclinm.2020.100518