The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed lo...

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Veröffentlicht in:	Haematologica (Roma) 2010-07, Vol.95 (7), p.1221-1225
Hauptverfasser:	ROSS, Fiona M, CHIECCHIO, Laura, DAGRADA, Gianpaolo, PROTHEROE, Rebecca K. M, STOCKLEY, David M, HARRISON, Christine J, CROSS, Nicholas C. P, SZUBERT, Alex J, DRAYSON, Mark T, MORGAN, Gareth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Brief Reports Disease Progression Female Hematologic and hematopoietic diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Monoclonal Gammopathy of Undetermined Significance - diagnosis Monoclonal Gammopathy of Undetermined Significance - genetics Multiple Myeloma - diagnosis Multiple Myeloma - genetics Prognosis Translocation, Genetic
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Zusammenfassung:	A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148,
ISSN:	0390-6078 1592-8721
DOI:	10.3324/haematol.2009.016329