Trandolapril and verapamil SR combination effectiveness in arterial hypertension patients

Aim. To study the effects of fixed4dose combined trandolapril and verapamil SR (Tarka) therapy on blood pressure (BP) and renin-angiotensin-aldosterone system (RAAS) patients with in essential arterial hypertension (EAH) and renal AH. Material and methods. The study included 20 patients with mild to moderate AH; 16 completed the study. EAH was diagnosed in 9 participants, secondary AH and chronic pyelonephritis – in 7. At baseline and 8 weeks later, office BP measurement, 24-hour BP monitoring (BPM), vectorcardiography and decartography parameters, renin activity (RA), aldosterone, potassium, microalbuminuria (MAU) level measurement were performed. Results. Target systolic BP (SBP) levels,